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Cayman Olsalazine (sodium salt)
List Price $190.00 Your Price $190.00
Cayman Olsalazine (sodium salt) - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-23661-1
MFG.PART: 23661-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Olsalazine is an orally bioavailable prodrug form of the anti-inflammatory agent 5-aminosalicylic acid (5-ASA; Item No. ) that is cleaved by bacterial azo reductases in the gut to generate active 5-ASA. In vitro, olsalazine increases ion transport in isolated rabbit distal ileum when applied to the luminal side (ED50 = 0.3 mm) and stimulates fluid transport in rat jejunum when used at a concentration of 5 mm., Olsalazine (150 mg/kg for 8 days) improves stool consistency and decreases occult and gross bleeding as well as myeloperoxidase (MPO) activity and leukotriene B4 (LTB4; Item No. ) levels in colon tissue in a mouse model of acute colitis induced by dextran sulfate (Item No. ). Olsalazine also inhibits bovine xanthine oxidase in vitro (IC50 = 3.4 mg/L) and lowers serum uric acid levels in a mouse model of hyperuricemia induced by oxonic acid (Item No. ) when administered at a dose of 20 mg/kg. Formulations containing olsalazine have been used in the treatment of inflammatory bowel disease (IBD) and ulcerative colitis.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
3,3-(1,2-
CAS Number
6054-98-4
Synonyms
- C.I. 14130
Molecular Formula
C14H8N2O6 • 2Na
Formula Weight
346.2
Purity
≥98%
Formulation
A crystalline solid
Solubility
- PBS (pH 7.2): 2 mg/mL
λmax
219, 253, 362 nm
SMILES
[O-]C(C1=C(O)C=CC(/N=N/C2=CC=C(O)C(C([O-])=O)=C2)=C1)=O.[Na+].[Na+]
InChi Code
InChI=1S/C14H10N2O6.2Na/c17-11-3-1-7(5-9(11)13(19)20)15-16-8-2-4-12(18)10(6-8)14(21)22;;/h1-6,17-18H,(H,19,20)(H,21,22);;/q;2*+1/p-2/b16-15+;;
InChi Key
ZJEFYLVGGFISGT-VRZXRVJBSA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-23661-1 |
|---|---|
| Supplier Part Number | 23661-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 6054-98-4 |
| Energy Star | No |
| Green | No |
| Controlled | N |