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Cayman Saxagliptin (hydrochloride)
List Price
$84.00
Your Price
$84.00
Cayman Saxagliptin (hydrochloride) - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-23697-10
MFG.PART:
23697-10
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Saxagliptin is a potent inhibitor of dipeptidyl peptidase 4 (DPP-4; Ki = 0.6 nM). It inhibits DPP-4 ex vivo (ED50 = 0.12 μmol/kg) in plasma from normal fasted rats. Saxagliptin (0.3-3 mg/kg) reduces plasma glucose levels in Zuckerfa/fa diabetic rats in a dose-dependent manner. Oral administration at doses ranging from 1-10 μmol/kg increases plasma insulin levels and improves glucose clearance in ob/ob mice, a transgenic model of obesity. Saxagliptin induces systolic and diastolic dysfunction, reduces contractile force, and exacerbates ischemia-reperfusion injury-induced cardiac dysfunction in isolated guinea pig hearts. Formulations containing saxagliptin have been used for the treatment of type 2 diabetes.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(1S,3S,5S)-2-
CAS Number
709031-78-7
Synonyms
- BMS-477118
Molecular Formula
C18H25N3O2 • HCl
Formula Weight
351.9
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 20 mg/mL
- DMSO: 20 mg/mL
- Ethanol: 10 mg/mL
- PBS (pH 7.2): 2 mg/mL
λmax
202 nm
SMILES
O=C(N1[C@H](C#N)C[C@H]2[C@@H]1C2)[C@H]([C@@]3(C[C@H](C4)C5)C[C@H]5C[C@@]4(O)C3)N.Cl
InChi Code
InChI=1S/C18H25N3O2.ClH/c19-8-13-2-12-3-14(12)21(13)16(22)15(20)17-4-10-1-11(5-17)7-18(23,6-10)9-17;/h10-15,23H,1-7,9,20H2;1H/t10-,11+,12-,13?,14+,15-,17+,18-;/m1./s1
InChi Key
TUAZNHHHYVBVBR-WYHYZCDFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-23697-10 |
|---|---|
| Supplier Part Number | 23697-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 709031-78-7 |
| Energy Star | No |
| Green | No |
| Controlled | N |