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Cayman PD 166793
List Price $189.00 Your Price $189.00
Cayman PD 166793 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-23762-10
MFG.PART: 23762-10
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
PD 166793 is a broad-spectrum matrix metalloproteinase (MMP) inhibitor (IC50s = 6.1, 0.047, 0.012, 7.2, 7.9, 0.008, and 0.24 μM for MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13CD, and MMP-14CD, respectively). It reverses peroxynitrite-induced decreases in contraction cease time, a measure of cardiac contractility, in isolated rat ventricular myocytes when used at a concentration of 2 μM. In vivo, PD 166793 (2 mg/kg per day, p.o.) reduces left ventricular (LV) peak wall stress in a porcine model of congestive heart failure. It reduces LV dilation and preserves systolic function in a rat model of progressive heart failure. PD 166793 also inhibits age-associated increases in aortic gelatinase and interstitial collagenase activity and mean arterial pressure in rats.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[(4-bromo
CAS Number
199850-67-4
Molecular Formula
C17H18BrNO4S
Formula Weight
412.3
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 50 mg/mL
- DMSO: 50 mg/mL
- DMSO:PBS (pH 7.2) (1:1): 0.5 mg/mL
- Ethanol: 10 mg/mL
λmax
204, 272 nm
SMILES
BrC1=CC=C(C2=CC=C(S(N[C@@H](C(C)C)C(O)=O)(=O)=O)C=C2)C=C1
InChi Code
InChI=1S/C17H18BrNO4S/c1-11(2)16(17(20)21)19-24(22,23)15-9-5-13(6-10-15)12-3-7-14(18)8-4-12/h3-11,16,19H,1-2H3,(H,20,21)/t16-/m0/s1
InChi Key
GJOCABIDMCKCEG-INIZCTEOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-23762-10 |
|---|---|
| Supplier Part Number | 23762-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 199850-67-4 |
| Energy Star | No |
| Green | No |
| Controlled | N |