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Cayman Alvimopan
List Price $184.00 Your Price $184.00
Cayman Alvimopan - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-23902-10
MFG.PART: 23902-10
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Alvimopan is a μ-opioid receptor antagonist (Ki = 0.47 nM). It is selective over the κ- and δ-opioid receptors (Kis= 100 nM and 12 nM, respectively). Alvimopan inhibits μ-opioid receptor-mediated GTP binding to CHO cell membranes with an IC50 value of 1.7 nM. It inhibits morphine-induced slowing of colorectal transit in mice with an ED50 value of 0.41 mg/kg. Alvimopan (0.3 and 1 mg/kg, p.o.) reduces inhibition of gastrointestinal (GI) transit induced by morphine, but not apraclonidine (Item No. ), in rats. Formulations containing alvimopan have been used in the treatment of opioid-induced bowel dysfunction.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[(2S)-2-[[(
CAS Number
156053-89-3
Synonyms
- ADL 8-2698
- LY246736
Molecular Formula
C25H32N2O4
Formula Weight
424.5
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 10 mg/mL
- DMSO: 20 mg/mL
- DMSO:PBS (pH 7.2) (1:3): 0.25 mg/mL
SMILES
OC1=CC=CC([C@]2(C)CCN(C[C@@H](C(NCC(O)=O)=O)CC3=CC=CC=C3)C[C@@H]2C)=C1
InChi Code
InChI=1S/C25H32N2O4/c1-18-16-27(12-11-25(18,2)21-9-6-10-22(28)14-21)17-20(24(31)26-15-23(29)30)13-19-7-4-3-5-8-19/h3-10,14,18,20,28H,11-13,15-17H2,1-2H3,(H,26,31)(H,29,30)/t18-,20-,25+/m0/s1
InChi Key
UPNUIXSCZBYVBB-JVFUWBCBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-23902-10 |
|---|---|
| Supplier Part Number | 23902-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| CAS Number | 156053-89-3 |
| Energy Star | No |
| Green | No |
| Controlled | N |