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Cayman SR 142948 (hydrochloride)
List Price $103.00 Your Price $103.00
Cayman SR 142948 (hydrochloride) - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-23911-1
MFG.PART: 23911-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
SR 142948 is an orally bioavailable non-peptide antagonist of neurotensin receptors (NTS; IC50s = 1.19, 0.32, and 3.96 nM for human recombinant NTS receptors expressed in CHO Cells, HT-29 cells, and adult rat brain membranes, respectively). It inhibits inositol phosphate formation in HT-29 cells (IC50 = 3.9 nM) and intracellular calcium accumulation in CHO Cells expressing human NTS receptors. SR 142948 (1 mg/kg, i.v.) inhibits the firing rate of rat ventral pallidum neurons with a longer duration of action than the NTS receptor antagonist SR 48692 (Item No. ). It also inhibits neurotensin-induced behavioral responses, including inhibition of neurotensin-induced turning behavior in mice when administered at doses ranging from 40 to 640 mg/kg and hypothermia and analgesia in rats and mice.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-[[[5-(2,6-
Molecular Formula
C39H51N5O6 • 2HCl
Formula Weight
758.8
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 10 mg/mL
- DMSO: 10 mg/mL
- Ethanol: 5 mg/mL
- PBS (pH 7.2): 0.1 mg/mL
λmax
202, 231 nm
SMILES
CN(CCCN(C)C(C1=CC=C(N2N=C(C(N[C@]3(C(O)=O)[C@H](C4)C[C@H]5C[C@@H]3C[C@@H]4C5)=O)C=C2C6=C(OC)C=CC=C6OC)C(C(C)C)=C1)=O)C.Cl.Cl
InChi Code
InChI=1S/C39H51N5O6.2ClH/c1-23(2)29-21-26(37(46)43(5)15-9-14-42(3)4)12-13-31(29)44-32(35-33(49-6)10-8-11-34(35)50-7)22-30(41-44)36(45)40-39(38(47)48)27-17-24-16-25(19-27)20-28(39)18-24;;/h8,10-13,21-25,27-28H,9,14-20H2,1-7H3,(H,40,45)(H,47,48);2*1H/t24-,25+,27-,28+,39-;;
InChi Key
AQJKZKHTPLUIAD-HAAOKSBBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-23911-1 |
|---|---|
| Supplier Part Number | 23911-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| Controlled | N |