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Cayman Metipranolol (hydrochloride)
List Price $41.00 Your Price $41.00
Cayman Metipranolol (hydrochloride) - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-24003-1
MFG.PART: 24003-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Metipranolol is a β-adrenergic receptor (β-AR) antagonist. It binds to primary rabbit iris and ciliary body homogenates (Ki = 34 nM) and inhibits relaxation induced by isoproterenol (Item No. ) in guinea pig atrium and by fenoterol (Item No. ) in rat uterus (PA2s = 8.3 and 8.4, respectively). In vitro, metipranolol (100 μM) inhibits anoxia-induced cell death in primary rat retinal cells and sodium nitroprusside-induced lipid peroxidation in rat primary retinal homogenates., In vivo, topical ocular application of metipranolol (0.3%) decreases α-chymotrypsin-induced increases in intraocular pressure (IOP) in rabbits. It also inhibits the blinking response to ocular tactile stimulation in rabbits when administered topically to the eye at a dose of 0.6%. Formulations containing metipranolol have been used in the treatment of elevated IOP in patients with ocular hypertension or glaucoma.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4-[2-hydroxy-
CAS Number
36592-77-5
Synonyms
- Trimepranol
Molecular Formula
C17H27NO4 • HCl
Formula Weight
345.9
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 50 mg/mL
- DMSO: 50 mg/mL
- Ethanol: 10 mg/mL
- PBS (pH 7.2): 5 mg/mL
λmax
203 nm
SMILES
CC1=C(OC(C)=O)C(C)=C(C)C(OCC(O)CNC(C)C)=C1.Cl
InChi Code
InChI=1S/C17H27NO4.ClH/c1-10(2)18-8-15(20)9-21-16-7-11(3)17(22-14(6)19)13(5)12(16)4;/h7,10,15,18,20H,8-9H2,1-6H3;1H
InChi Key
BLWNYSZZZWQCKO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 2 years
| SKU | CAYM-24003-1 |
|---|---|
| Supplier Part Number | 24003-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 36592-77-5 |
| Energy Star | No |
| Green | No |
| Controlled | N |