Cayman Dipivefrin (hydrochloride)

Dipivefrin is a prodrug of epinephrine that is hydrolyzed by cholinesterase and other esterases in the cornea to epinephrine.¹ It reduces the density of cultured bovine primary trabecular meshwork cells (IC₅₀ = 115 µM).² Additionally, it induces an elongated, fibroblast-like morphology and disrupts the actin cytoskeleton in bovine primary trabecular meshwork cells when used at a concentration of 103 µM.² In cultured bovine corneal endothelial cells, dipivefrin (28 µM) enhances calcium signaling and induces cytotoxicity.^3,4 Dipivefrin also suppresses primary human corneal keratinocyte proliferation when used at a concentration of 280 µM.⁵ Formulations containing dipivefrin have been used alone and in combination with β-adrenergic receptor antagonists for the treatment of glaucoma.

WARNING This product is not for human or veterinary use.