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Cayman Substance P (trifluoroacetate salt)
List Price $283.00 Your Price $283.00
Cayman Substance P (trifluoroacetate salt) - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-24035-10
MFG.PART: 24035-10
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Substance P is tachykinin neuropeptide that selectively binds to neurokinin 1 (NK1) receptors (Kis = 0.14 and 300 nM for NK1 and NK3, respectively) and has diverse biological activities.1,2 It is an endogenous peptide expressed in the central and peripheral nervous systems, including the enteric nervous system and in immune cells.2 Substance P is released with other neurotransmitters in the dorsal horn of the spinal cord following noxious peripheral stimulation and induces pain through NK1 receptors.3 The NK1 receptor is internalized following substance P binding, and in a rat hindpaw model of inflammation it is internalized in a greater number of spinal cord neurons following a mechanical or non-noxious stimuli, indicating a role for substance P in inflammation and hyperalgesia.4 Substance P is also involved in depression, anxiety, seizures, and emesis among other functions.2
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(S)-2-((S)-1-
CAS Number
148470-19-3
Molecular Formula
C63H98N18O13S • XCF3COOH
Formula Weight
1347.6
Purity
≥95%
Formulation(Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
- Water: 1 mg/mL
SMILES
O=C(N[C@@H](CCCCN)C(N1CCC[C@H]1C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC2=CC=CC=C2)C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N)=O)CCSC)=O)CC(C)C)=O)=O)CC3=CC=CC=C3)=O)=O)=O)=O)=O)[C@H]4N(C([C@@H](N)CCCNC(N)=N)=O)CCC4.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C63H98N18O13S.C2HF3O2/c1-37(2)33-45(57(89)74-41(53(68)85)27-32-95-3)73-52(84)36-72-54(86)46(34-38-15-6-4-7-16-38)78-58(90)47(35-39-17-8-5-9-18-39)79-56(88)42(23-25-50(66)82)75-55(87)43(24-26-51(67)83)76-59(91)49-22-14-31-81(49)62(94)44(20-10-11-28-64)77-60(92)48-21-13-30-80(48)61(93)40(65)19-12-29-71-63(69)70;3-2(4,5)1(6)7/h4-9,15-18,37,40-49H,10-14,19-36,64-65H2,1-3H3,(H2,66,82)(H2,67,83)(H2,68,85)(H,72,86)(H,73,84)(H,74,89)(H,75,87)(H,76,91)(H,77,92)(H,78,90)(H,79,88)(H4,69,70,71);(H,6,7)/t40-,41-,42-,43-,44-,45-,46-,47-,48-,49-;/m0./s1
InChi Key
HJUBUMANGKVTGH-HDKZLILXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-24035-10 |
|---|---|
| Supplier Part Number | 24035-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 148470-19-3 |
| Energy Star | No |
| Green | No |
| Controlled | N |