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Cayman Genz-644282
List Price $44.00 Your Price $44.00
Cayman Genz-644282 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-24193-1
MFG.PART: 24193-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Genz-644282 is a topoisomerase I (TOP-I) inhibitor that inhibits TOP-I-mediated DNA cleavage 10-fold more potently than the TOP-I inhibitor topotecan (Item No. ). It inhibits the growth of and is cytotoxic to human and mouse bone marrow cells in a colony-forming unit assay (IC50s = 0.4 and 2.3 nM, respectively; IC90s = 1.2 and 8.4 nM, respectively). It also inhibits the growth of and is cytotoxic to human tumor cell lines (IC50s = 0.15-2 nM; IC90s = 0.7-8.3 nM). Genz-644282 inhibits tumor growth in mouse xenograft models when administered at doses ranging from 1.36 to 2.7 mg/kg.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2,3-dimethoxy
CAS Number
529488-28-6
Molecular Formula
C22H21N3O5
Formula Weight
407.4
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 0.5 mg/mL
- DMSO: 0.5 mg/mL
- DMSO:PBS (pH 7.2) (1:20): 0.04 mg/mL
- Ethanol: 0.2 mg/mL
λmax
288 nm
SMILES
COC1=CC(C(N2CCNC)=O)=C(C=C1OC)C3=C2C4=CC(OCO5)=C5C=C4N=C3
InChi Code
InChI=1S/C22H21N3O5/c1-23-4-5-25-21-14-8-19-20(30-11-29-19)9-16(14)24-10-15(21)12-6-17(27-2)18(28-3)7-13(12)22(25)26/h6-10,23H,4-5,11H2,1-3H3
InChi Key
BAORCAMWLWRZQG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-24193-1 |
|---|---|
| Supplier Part Number | 24193-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 529488-28-6 |
| Energy Star | No |
| Green | No |
| Controlled | N |