Cayman Nemorosone

Nemorosone is a polycyclic polyprenylated acylphloroglucinol (PPAP) originally isolated from C. rosea that has antiproliferative properties.¹ Nemorosone inhibits growth of NB69, Kelly, SK-N-AS, and LAN-1 neuroblastoma cells (IC₅₀s = 3.1-6.3 µM), including several drug-resistant clones, but not MRC-5 human embryonic fibroblasts (IC₅₀ = >40 µM).² It increases DNA fragmentation in LAN-1 cells in a dose-dependent manner, and decreases N-Myc protein levels and phosphorylation of ERK1/2 by MEK1/2. Nemorosone also inhibits growth of Capan-1, AsPC-1, and MIA-PaCa-2 pancreatic cancer cells (IC₅₀s = 4.5-5.0 µM following a 72-hour treatment) but not human dermal and foreskin fibroblasts (IC₅₀s = >35 µM).¹ It induces apoptosis, abolishes the mitochondrial membrane potential, and increases cytosolic calcium concentration in pancreatic cancer cells in a dose-dependent manner. Nemorosone activates the caspase cascade in a dose-dependent manner and inhibits cell cycle progression, increasing the proportion of cells in the g₀/g₁ phase, in both neuroblastoma and pancreatic cancer cells.^1,2 Nemorosone (50 mg/kg, i.p., per day) also reduces tumor growth in an MIA-PaCa-2 mouse xenograft model.³

WARNING This product is not for human or veterinary use.