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Cayman (Ala1)-PAR4 (1-6) amide (mouse) (trifluoroacetate salt)
List Price $179.00 Your Price $179.00
Cayman (Ala1)-PAR4 (1-6) amide (mouse) (trifluoroacetate salt) - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-24258-1
MFG.PART: 24258-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
(Ala1)-PAR4 (1-6) amide (mouse) is a peptide agonist of proteinase-activated receptor 4 (PAR4) that induces aggregation of rat and human platelets in vitro (EC50s = 15 and 60 μM, respectively)., It reduces expression of glycoprotein (GP) Ib, and increases expression of GPIIb/IIIa on the surface of human platelets. (Ala1)-PAR4 (1-6) amide (mouse) induces relaxation of isolated rat aortic rings and contraction of rat gastric longitudinal muscle strips (EC50s = 11 and 110 μM, respectively) as well as inhibits calcium mobilization evoked by capsaicin (Item No. ) in rat sensory neurons., In vivo, (Ala1)-PAR4 (1-6) amide (mouse) (1-100 µg) increases latency to paw withdrawal and the nociceptive threshold in response to thermal and mechanical stimuli. (Ala1)-PAR4 (1-6) amide (mouse) (200 µg) also increases paw thickness in a rat paw edema assay.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
L-alanyl-L-
Synonyms
- AY-NH2
- AYPGKF-NH2
- H-Ala-Tyr-Pro-Gly-Lys-Phe-NH2
- PAR4-AP
- Proteinase-Activated Receptor 4 Activating Peptide
Molecular Formula
C34H48N8O7 • XCF3COOH
Formula Weight
680.8
Purity
≥95%
Formulation
A lyophilized powder
Solubility
- Water: 1 mg/mL
SMILES
NC([C@@H](NC([C@H](CCCCN)NC(CNC([C@H]1N(C([C@H](CC2=CC=C(O)C=C2)NC([C@H](C)N)=O)=O)CCC1)=O)=O)=O)CC3=CC=CC=C3)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C34H48N8O7.C2HF3O2/c1-21(36)31(46)41-27(19-23-12-14-24(43)15-13-23)34(49)42-17-7-11-28(42)33(48)38-20-29(44)39-25(10-5-6-16-35)32(47)40-26(30(37)45)18-22-8-3-2-4-9-22;3-2(4,5)1(6)7/h2-4,8-9,12-15,21,25-28,43H,5-7,10-11,16-20,35-36H2,1H3,(H2,37,45)(H,38,48)(H,39,44)(H,40,47)(H,41,46);(H,6,7)/t21-,25-,26-,27-,28-;/m0./s1
InChi Key
BGPJLFVICWHITH-HKJXYENISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-24258-1 |
|---|---|
| Supplier Part Number | 24258-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| Controlled | N |