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Cayman ARN726
List Price $38.00 Your Price $38.00
Cayman ARN726 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-24259-1
MFG.PART: 24259-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
ARN726 is an inhibitor of N-acylethanolamine acid amidase (NAAA; IC50s = 27 and 63 nM for the human and rat enzyme, respectively). It is selective for NAAA over fatty acid amide hydrolase (FAAH) and acid ceramidase (IC50s = >100 and 12.5 μM, respectively), as well as a panel of 28 lipid metabolism- and inflammation-related enzymes at 10 μM. ARN726 (1-30 mg/kg) decreases lung myeloperoxidase activity and pleural exudate TNF-α levels in a mouse model of carrageenan-induced lung inflammation. It inhibits NAAA and reverses complete Freunds adjuvant-induced decreases in palmitoyl ethanolamide (PEA; Item No. ) and oleoyl ethanolamide (OEA; Item No. ) levels in inflamed paw tissue in a rat model of arthritis.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[(3S)-2-
CAS Number
1628343-77-0
Molecular Formula
C14H24N2O3
Formula Weight
268.4
Purity
≥95%
Formulation
A crystalline solid
Solubility
- DMF: 33 mg/mL
- DMSO: 33 mg/mL
- Ethanol: 33 mg/mL
- Ethanol:PBS (pH 7.2) (1:4): 0.20 mg/mL
SMILES
O=C(N[C@H]1CNC1=O)OCCCCC2CCCCC2
InChi Code
InChI=1S/C14H24N2O3/c17-13-12(10-15-13)16-14(18)19-9-5-4-8-11-6-2-1-3-7-11/h11-12H,1-10H2,(H,15,17)(H,16,18)/t12-/m0/s1
InChi Key
FNLUJRBWJBUJTC-LBPRGKRZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 2 years
| SKU | CAYM-24259-1 |
|---|---|
| Supplier Part Number | 24259-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1628343-77-0 |
| Energy Star | No |
| Green | No |
| Controlled | N |