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Cayman ARN14686
List Price $54.00 Your Price $54.00
Cayman ARN14686 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-24261-1
MFG.PART: 24261-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
ARN14686 is an activity-based affinity probe for the detection of N-acylethanolamine acid amidase (NAAA) using click chemistry. It binds covalently to the N-terminal cysteine of catalytically active NAAA to form a thioester adduct. ARN14686 inhibits the hydrolysis of the NAAA substrate PAMCA in HEK293 cells (IC50s = 6 and 13 nM for human and rat recombinant enzymes, respectively) and is selective for NAAA over acid ceramidase (IC50 = 1,200 nM for the rat enzyme). It labels NAAA in HEK293 cells overexpressing human or rat recombinant NAAA and, when used at concentrations of 1 and 10 µM, in rat lung lysosomal fractions in vitro. It also detects NAAA in lung lysosomal fractions following intravenous administration at a dose of 10 mg/kg in rats. ARN14686 (3 mg/kg) has been used to determine that catalytically active NAAA is present in inflamed rat paw in a complete Freund’s adjuvant model of inflammation.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[(3S)-2-oxo-
CAS Number
1628345-10-7
Synonyms
- Click Tag™ ARN14686
Molecular Formula
C15H24N2O3
Formula Weight
280.4
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- Ethanol: 1 mg/mL
SMILES
O=C(N[C@H]1CNC1=O)OCCCCCCCCCC#C
InChi Code
InChI=1S/C15H24N2O3/c1-2-3-4-5-6-7-8-9-10-11-20-15(19)17-13-12-16-14(13)18/h1,13H,3-12H2,(H,16,18)(H,17,19)/t13-/m0/s1
InChi Key
XEXRAYPXQNELAS-ZDUSSCGKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 2 years
| SKU | CAYM-24261-1 |
|---|---|
| Supplier Part Number | 24261-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1628345-10-7 |
| Energy Star | No |
| Green | No |
| Controlled | N |