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Cayman MCH (human, mouse, rat) (trifluoroacetate salt)
List Price $416.00 Your Price $416.00
Cayman MCH (human, mouse, rat) (trifluoroacetate salt) - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-24462-1
MFG.PART: 24462-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Melanin-concentrating hormone (MCH) is an endogenous hypothalamic neuropeptide hormone that is an agonist at MCH receptors. It binds to MCH1 and MCH2 receptors (IC50s = 0.17 and 2.9 nM, respectively, for the human receptors) and stimulates calcium accumulation with EC50 values of 28 and 50 nM, respectively, in an aequorin bioluminescence functional assay. MCH also binds to the rat MCH1 receptor (Ki = 0.16 nM in CHO Cells), stimulates calcium accumulation (EC50 = 1.79 nM), and inhibits intracellular cAMP accumulation induced by forskolin (Item No. ; EC50 = 0.46 nM). It binds to mouse MCH receptors on melanoma B16 cells (Ki = 33 nM) and dose-dependently activates the mitogen-activated protein kinase (MAPK) signaling pathway. MCH (5 nmol/kg, i.c.v.) increases cumulative food intake in rats.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
L-α-aspartyl-
Synonyms
- Melanin-Concentrating Hormone
Molecular Formula
C105H160N30O26S4 • XCF3COOH
Formula Weight
2386.8
Purity
≥95%
Formulation
A lyophilized powder
Solubility
- Water: 1 mg/mL
SMILES
[H]N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N1CCC[C@H]1C2=O)=O)=O)CC3=CC=C(O)C=C3)=O)=O)=O)=O)=O)CCSC)=O)CSSC[C@H](N2)C(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@@H](C(C)C)C(O)=O)=O)=O)CC4=CNC5=C4C=CC=C5)=O)=O)=O)=O)CCSC)=O)CC(O)=O)=O)CC6=CC=CC=C6)=O)CC(O)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C105H160N30O26S4.C2HF3O2/c1-53(2)42-70-86(144)118-50-80(138)119-64(24-16-36-114-103(108)109)90(148)133-83(55(5)6)100(158)130-73(45-58-28-30-60(136)31-29-58)93(151)124-69(26-18-38-116-105(112)113)101(159)135-39-19-27-78(135)99(157)132-77(98(156)128-74(46-59-49-117-63-23-15-14-22-61(59)63)95(153)121-66(32-33-79(107)137)91(149)134-84(56(7)8)102(160)161)52-165-164-51-76(97(155)123-68(35-41-163-10)88(146)126-70)131-87(145)65(25-17-37-115-104(110)111)120-92(150)71(43-54(3)4)127-89(147)67(34-40-162-9)122-96(154)75(48-82(141)142)129-94(152)72(44-57-20-12-11-13-21-57)125-85(143)62(106)47-81(139)140;3-2(4,5)1(6)7/h11-15,20-23,28-31,49,53-56,62,64-78,83-84,117,136H,16-19,24-27,32-48,50-52,106H2,1-10H3,(H2,107,137)(H,118,144)(H,119,138)(H,120,150)(H,121,153)(H,122,154)(H,123,155)(H,124,151)(H,125,143)(H,126,146)(H,127,147)(H,128,156)(H,129,152)(H,130,158)(H,131,145)(H,132,157)(H,133,148)(H,134,149)(H,139,140)(H,141,142)(H,160,161)(H4,108,109,114)(H4,110,111,115)(H4,112,113,116);(H,6,7)/t62-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,83-,84-;/m0./s1
InChi Key
OXGQGVLSZHKNEA-RHYDOJFISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-24462-1 |
|---|---|
| Supplier Part Number | 24462-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| Controlled | N |