Cayman Pancreatic Polypeptide (human) (trifluoroacetate salt)

Name: Cayman Pancreatic Polypeptide (human) (trifluoroacetate salt)
SKU: CAYM-24555-500
Price: 336.00 USD

List Price $336.00 Your Price $336.00

Cayman Pancreatic Polypeptide (human) (trifluoroacetate salt) - CAYM (Additional S&H Or Hazmat Fees May Apply)

NETA PART: CAYM-24555-500

MFG.PART: 24555-500

UNSPSC: 12352200

Manufacturer: Cayman

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Description

Product Description

Pancreatic polypeptide is an agonist of neuropeptide Y (NPY) receptors that reduces forskolin-induced cAMP accumulation in L-M(TK-) cells recombinantly expressing human and rat Y₄ receptors (EC₅₀s = 87.1 and 36.3 pM, respectively). It binds to Y₁ and Y₅ receptors with K_i values of 19 and 3.9 nM, respectively, for human and 50 and 2.4 nM, respectively, for rhesus monkey receptors. Pancreatic polypeptide also binds to rabbit Y₁, Y₂, Y₄, and Y₅ receptors (K_is = 0.39, 0.087, 0.79, and 0.24 nM, respectively). It induces contractile responses in isolated rat colon with EC₅₀ values of 1.6 and 0.7 nM for ascending and descending colon segments, respectively. In vivo, pancreatic polypeptide (0.7-7 nmol, i.c.v.) increases food intake in rats.

WARNING This product is not for human or veterinary use.

Technical Information

Formal Name

L-alanyl-L-prolyl-L-leucyl-L-α-glutamyl-L-prolyl-L-valyl-L-tyrosyl-L-prolylglycyl-L-α-aspartyl-L-asparaginyl-L-alanyl-L-threonyl-L-prolyl-L-α-glutamyl-L-glutaminyl-L-methionyl-L-alanyl-L-glutaminyl-L-tyrosyl-L-alanyl-L-alanyl-L-α-aspartyl-L-leucyl-L-arginyl-L-arginyl-L-tyrosyl-L-isoleucyl-L-asparaginyl-L-methionyl-L-leucyl-L-threonyl-L-arginyl-L-prolyl-L-arginyl-L-tyrosinamide, trifluoroacetate salt

CAS Number

75976-10-2

Molecular Formula

C₁₈₅H₂₈₇N₅₃O₅₄S₂

Formula Weight

4181.8

Purity

≥95%

Formulation

A lyophilized powder

Solubility

Water: 1 mg/mL

SMILES

NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@@H]1CCCN1C([C@H](CCCNC(N)=N)NC([C@@]([C@@H](C)O)([H])NC([C@H](CC(C)C)NC([C@@H](NC([C@H](CC(N)=O)NC([C@@]([C@H](CC)C)([H])NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCC(N)=O)NC([C@@H](NC([C@@H](NC([C@H](CCC(N)=O)NC([C@H](CCC(O)=O)NC([C@@H]2CCCN2C([C@@]([C@@H](C)O)([H])NC([C@@H](NC([C@H](CC(N)=O)NC([C@@H](NC(CNC([C@@H]3CCCN3C([C@@H](NC([C@H](C(C)C)NC([C@@H]4CCCN4C([C@H](CCC(O)=O)NC([C@H](CC(C)C)NC([C@@H]5CCCN5C([C@@H](N[H])C)=O)=O)=O)=O)=O)=O)CC6=CC=C(O)C=C6)=O)=O)=O)CC(O)=O)=O)=O)C)=O)=O)=O)=O)=O)CCSC)=O)C)=O)=O)CC7=CC=C(O)C=C7)=O)C)=O)C)=O)CC(O)=O)=O)=O)=O)=O)CC8=CC=C(O)C=C8)=O)=O)=O)CCSC)=O)=O)=O)=O)=O)=O)CC9=CC=C(O)C=C9)=O

InChi Code

InChI=1S/C185H287N53O54S2/c1-20-92(10)144(175(286)228-125(84-137(190)248)164(275)215-115(64-75-294-19)159(270)222-121(78-90(6)7)167(278)232-145(98(16)239)176(287)219-116(33-24-68-203-185(198)199)178(289)236-71-27-36-131(236)170(281)216-110(32-23-67-202-184(196)197)154(265)220-118(147(191)258)79-100-39-47-104(241)48-40-100)231-168(279)123(81-102-43-51-106(243)52-44-102)225-155(266)109(31-22-66-201-183(194)195)211-153(264)108(30-21-65-200-182(192)193)212-162(273)119(76-88(2)3)223-166(277)127(86-142(256)257)221-150(261)95(13)205-148(259)94(12)207-160(271)122(80-101-41-49-105(242)50-42-101)224-158(269)111(55-59-134(187)245)210-149(260)96(14)206-152(263)114(63-74-293-18)214-156(267)112(56-60-135(188)246)213-157(268)113(57-61-139(250)251)217-171(282)132-37-29-73-238(132)181(292)146(99(17)240)233-151(262)97(15)208-161(272)124(83-136(189)247)226-165(276)126(85-141(254)255)209-138(249)87-204-169(280)129-34-25-70-235(129)180(291)128(82-103-45-53-107(244)54-46-103)229-174(285)143(91(8)9)230-173(284)133-38-28-72-237(133)179(290)117(58-62-140(252)253)218-163(274)120(77-89(4)5)227-172(283)130-35-26-69-234(130)177(288)93(11)186/h39-54,88-99,108-133,143-146,239-244H,20-38,55-87,186H2,1-19H3,(H2,187,245)(H2,188,246)(H2,189,247)(H2,190,248)(H2,191,258)(H,204,280)(H,205,259)(H,206,263)(H,207,271)(H,208,272)(H,209,249)(H,210,260)(H,211,264)(H,212,273)(H,213,268)(H,214,267)(H,215,275)(H,216,281)(H,217,282)(H,218,274)(H,219,287)(H,220,265)(H,221,261)(H,222,270)(H,223,277)(H,224,269)(H,225,266)(H,226,276)(H,227,283)(H,228,286)(H,229,285)(H,230,284)(H,231,279)(H,232,278)(H,233,262)(H,250,251)(H,252,253)(H,254,255)(H,256,257)(H4,192,193,200)(H4,194,195,201)(H4,196,197,202)(H4,198,199,203)/t92-,93-,94-,95-,96-,97-,98+,99+,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,143-,144-,145-,146-/m0/s1

InChi Key

HFDKKNHCYWNNNQ-YOGANYHLSA-N

Shipping & Storage Information

Storage

-20°C

Shipping

Room Temperature in continental US; may vary elsewhere

Stability

≥ 4 years

Specifications

More Information
SKU	CAYM-24555-500
Supplier Part Number	24555-500
UM	EA
UNSPSC	12352200
Manufacturer	Cayman
MSDS URL	Click here
Temperature	-20
Refrigerated-Frozen	Y
CountryOfOrigin	United States
ProductLine	CAYM
Qty	1
MinOrderQty	1
Weight	7.000000
Lead Time	5
Hazardous	N
CAS Number	75976-10-2
Energy Star	No
Green	No
Controlled	N

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NETA PART NO.	Quantity

Cayman Pancreatic Polypeptide (human) (trifluoroacetate salt)

Product Description

Technical Information

Shipping & Storage Information

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