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Cayman ICA 121431
List Price
$462.00
Your Price
$462.00
Cayman ICA 121431 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-24669-25
MFG.PART:
24669-25
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
ICA 121431 is a voltage-gated sodium channel (Nav) blocker that selectively blocks Nav1.1 and Nav1.3 over Nav1.4, and Nav1.5-1.8 channels (IC50s = <20, 19, 240, and >10,000 nM, respectively).1 It induces a concentration-dependent hyperpolarizing shift in voltage dependence of inactivation of Nav1.3 channels at a concentration 1 μM but has no effect on resting channels. Substitution of the Nav1.3 domain IV voltage-sensor domain (VSD4) with the Nav1.5 VSD4 reduces ICA 121431 potency by approximately 500-fold.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
α-phenyl-N-
CAS Number
313254-51-2
Molecular Formula
C23H19N3O3S2
Formula Weight
449.5
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 15 mg/mL
- DMSO: 15 mg/mL
- DMSO:PBS (pH 7.2) (1:1): 0.5 mg/mL
- Ethanol: 0.1 mg/mL
λmax
205, 260, 287 nm
SMILES
O=C(NC1=CC=C(S(NC2=NC=CS2)(=O)=O)C=C1)C(C3=CC=CC=C3)C4=CC=CC=C4
InChi Code
InChI=1S/C23H19N3O3S2/c27-22(21(17-7-3-1-4-8-17)18-9-5-2-6-10-18)25-19-11-13-20(14-12-19)31(28,29)26-23-24-15-16-30-23/h1-16,21H,(H,24,26)(H,25,27)
InChi Key
URSQNPPONHUJDL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-24669-25 |
|---|---|
| Supplier Part Number | 24669-25 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 313254-51-2 |
| Energy Star | No |
| Green | No |
| Controlled | N |