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Cayman AG-14361
List Price $49.00 Your Price $49.00
Cayman AG-14361 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-24677-1
MFG.PART: 24677-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
AG-14361 is an inhibitor of poly(ADP-ribose) polymerase 1 (PARP1; Ki = 6.3 nM for the human enzyme). It inhibits PARP1 activity in permeabilized and intact SW620 cells (IC50s = 29 and 14 nM, respectively). AG-14361 (0.4 µM) potentiates the growth inhibitory effects of temozolomide (Item No. ) in HCT116, A2480, and CP70 cells and of the topoisomerase I inhibitor topotecan (Item No. ) by greater than three-fold in PARP1+/+ primary embryonic fibroblasts., It slows the rejoining of camptothecin-induced DNA strand breaks. AG-14361 also inhibits cell growth in a PARP1-independent manner with GI50 values of 66 and 65 µM, respectively, in cell lines derived from PARP1+/+ and PARP1-/- mice. AG-14361 (15 mg/kg), in combination with temozolomide, leads to tumor regression in an SW620 mouse xenograft model.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-[4-[(dimethyl
CAS Number
328543-09-5
Molecular Formula
C19H20N4O
Formula Weight
320.4
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 10 mg/mL
- DMSO: 20 mg/mL
- Ethanol: 2 mg/mL
- PBS (pH 7.2): 0.2 mg/mL
λmax
210, 240, 312 nm
SMILES
O=C1NCCN2C3=C1C=CC=C3N=C2C4=CC=C(CN(C)C)C=C4
InChi Code
InChI=1S/C19H20N4O/c1-22(2)12-13-6-8-14(9-7-13)18-21-16-5-3-4-15-17(16)23(18)11-10-20-19(15)24/h3-9H,10-12H2,1-2H3,(H,20,24)
InChi Key
SEKJSSBJKFLZIT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-24677-1 |
|---|---|
| Supplier Part Number | 24677-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 328543-09-5 |
| Energy Star | No |
| Green | No |
| Controlled | N |