Cayman CA-074

CA-074 is a selective epoxysuccinyl peptide inhibitor of the cysteine protease cathepsin B (K_is = 0.0087, 75, and 233 μM for rat cathepsin B, H, and L, respectively). It inhibits degradation of DQ-collagen IV and DQ-collagen I in 4T1.2 breast cancer cells in a concentration-dependent manner and reduces the number of lung and bone metastases in a 4T1.2 murine mammary cancer model, without affecting primary tumor growth, when administered at a dose of 50 mg/kg. CA-074 (0.1 and 0.2 mg/animal per day) reduces mercury-induced increases in expression of TNF-α, IL-1β, and the inflammasome component NRLP3 and decreases the severity of mercury-induced skin induration in mice. CA-074 also reduces ischemia-induced hippocampal neuron cell death in monkeys.

WARNING This product is not for human or veterinary use.