Cayman Neuropeptide Y (13-36) (human, rat) (trifluoroacetate salt)

Neuropeptide Y (NPY) (13-36) is a C-terminal fragment of NPY, a neuropeptide involved in controlling appetite, blood pressure, cardiac contractility, and intestinal secretion.¹ NPY (13-36) is an agonist of the NPY receptor Y₂ with K_i values of 1.28 and 2.62 nM for the rat recombinant receptor in CHO Cells and in rat jejunal crypt cell membranes, respectively.² It inhibits forskolin-induced cAMP accumulation with EC₅₀ values of 300, 2.2, >1,000, and 20 at Y₁, Y₂, Y₄, and Y₅ receptors, respectively, in vitro .³ NPY (13-36) inhibits basal short circuit currents (EC₅₀ = ~2 µM) and electrical field stimulated-secretory responses in isolated rat jejunal mucosa (EC₅₀ = ~200 nM) but does SO less potently than NPY (Item Nos. 24716 | 15071).⁴ NPY (13-36) also reduces the frequency of spontaneous excitatory postsynaptic currents (EPSCs) in the CA3 region of hippocampal slices from wild-type but not Y₅ receptor knockout mice.⁵

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