Cayman Atractylenolide III

Atractylenolide III is a sesquiterpene that has been isolated from Atractylodes and has diverse biological activities, including anti-inflammatory, anti-angiogenic, pro- and anti-apoptotic, and neuroprotective properties.^1,2,3,4,5 It inhibits the release of nitric oxide (NO), prostaglandin E₂ (PGE₂; Item No. 14010), TNF-α, and IL-6 induced by LPS from RAW264.7 macrophages when used at a concentration of 50 µM.¹ Atractylenolide III (100 µM) induces apoptosis and cell cycle arrest, as well as increases caspase-3, caspase-9, and poly(ADP-ribose) polymerase (PARP) cleavage in A549 human lung carcinoma cells.³ However, in primary embryonic mouse cerebral cortical neurons, it inhibits glutamate-induced apoptosis and DNA fragmentation when used at a concentration of 40 µM.⁴ It inhibits angiogenesis in an MDA-MB-231 human breast cancer mouse xenograft model when administered at a dose of 25 mg/kg per day.² Atractylenolide III (0.6 mg/kg per day) also decreases the latency to find the platform in the Morris water maze in a rat model of learning deficits induced by high-dose homocysteine.⁵

WARNING This product is not for human or veterinary use.