Cayman Chicoric Acid

Chicoric acid is a dicaffeoyl ester that has been found in C. intybus with diverse biological activities.¹ Chicoric acid (50-200 μg/mL) dose-dependently reduces the viability of Caco-2 and HCT116 human colorectal cancer cells.² It inhibits HIV integrase activities, including 3-processing of a DNA oligonucleotide and integration with template DNA (IC₅₀s = 1.1 and 0.8 μM, respectively).³ Chicoric acid (0.5-10 μM) noncompetitively inhibits integration of HIV DNA by HIV integrase and, at concentrations greater than or equal to 5 μM, inhibits HIV entry into H9 cells.⁴ Oral administration of chicoric acid (10 and 30 mg/kg) reduces hepatic lipid accumulation, lipid peroxidation, and fibrosis, inhibits production of pro-inflammatory cytokines and activation of NF-kB, and activates the AMPK signaling pathway in a mouse model of non-alcoholic steatohepatitis (NASH) induced by a methionine and choline-deficient diet.⁵ Chicoric acid (2 mg/kg) also reduces blood glucose levels by 54% in mice with streptozotocin-induced diabetes.⁶

WARNING This product is not for human or veterinary use.