Cayman Saikosaponin A

Saikosaponin A is a triterpenoid saponin with diverse biological activities, including anti-inflammatory, antiallergic, anticonvulsive, antiproliferative, and antiviral properties.^,,, Saikosaponin A reduces expression of TNF-α, IL-6, and IL-1β in primary mouse macrophages stimulated by LPS. It also increases the survival rate in mice with LPS-induced lethal endotoxemia in a dose-dependent manner. Saikosaponin A (20 mg/kg, i.v., per day) reduces weight loss, brain edema, blood-brain barrier disruption, and IL-6 and TNF-α protein levels in the ipsilateral cortex compared to control animals in a rat model of traumatic brain injury. It also reduces the number of nasal rubs and levels of serum TNF-α in an ovalbumin-sensitized allergic rhinitis mouse model in vivo when administered at a dose of 8 mg/kg. It reduces the duration and frequency of epileptiform activity in rat hippocampal CA1 neurons in a dose-dependent manner in a 4-aminopyridine (4-AP; Item No. ) seizure model. Saikosaponin A (20 µM) decreases viability in six human colon carcinoma (HCC), H358 lung and MCF-7 breast cancer, as well as Jurkat and K582 leukemia cell lines. It also prolongs tumor growth inhibition in LoVo and SW480 HCC mouse xenograft models in vivo when used at a dose of 2 mg/kg.

WARNING This product is not for human or veterinary use.