Cayman Baohuoside I

Baohuoside I is a flavonoid that has been isolated from E. koreanum and has diverse biological activities, including enzyme inhibitory, cytoprotective, neuroprotective, antiproliferative, and erectile function properties.^,,,, It inhibits human recombinant phosphodiesterase 5A1 (PDE5A1; IC₅₀ = 0.16 μM) in a cell-free assay and protects PC12 rat adrenal cells from hydrogen peroxide-induced death when used at a concentration of 25 μM.^, Baohuoside I inhibits the proliferation of HeLa human cervical, MM96E human melanoma, HL-60 human leukemia, and L1210 mouse leukemia cancer cells (IC₅₀s = 7.3, 7.5, 3.6, and 2.8 μg/mL, respectively). It decreases hippocampal neuronal death and the latency to find the platform in the Morris water maze in a rat model of neurodegeneration induced by streptozotocin (STZ; Item No. ) when administered at a dose of 10 mg/kg per day. Baohuoside I (10 mg/kg per day) also increases intracavernous pressure (ICP) in response to electrical stimulation of the cavernous nerve in an STZ-induced diabetic mouse model of erectile dysfunction.

WARNING This product is not for human or veterinary use.