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Cayman Cynaropicrin
List Price
$90.00
Your Price
$90.00
Cayman Cynaropicrin - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-25099-1
MFG.PART:
25099-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Cynaropicrin is a sesquiterpene lactone originally isolated from artichoke (C. scolymus) that has diverse biological activities.,,,, It inhibits the growth of SKOV3, LOX-IMVI, A549, MCF-7, HCT15, and PC-3 cancer cells (IC50s = 1.1-8.7 μg/mL). Cynaropicrin inhibits hepatitis C virus (HCV) replication in Huh7.5 cells with EC50 values ranging from 0.4 to 1.4 μM for genotypes 1a, 1b, 2b, 3a, 4a, 5a, 6a, and 7a. It inhibits release of TNF-α and nitric oxide (NO) from LPS-stimulated RAW264.7 cells (IC50s = 8.24 and 1.1 μM, respectively) as well as LPS-induced lymphocyte proliferation (IC50 = 0.9 μM). Cynaropicrin inhibits the growth of T. cruzi bloodstream trypomastigotes isolated from infected mice (EC50 = 1 μg/mL). It also exhibits antifeedant activity against S. granarius beetles, T. confusum larvae, and T. granarium larvae.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-(hydroxy
CAS Number
35730-78-0
Molecular Formula
C19H22O6
Formula Weight
346.4
Purity
≥98%
Formulation
A solution in ethanol
Solubility
- DMF: miscible
- DMSO: miscible
- Ethanol: miscible
- Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/mL
SMILES
C=C([C@@H](O)C1)[C@@]2([H])[C@]1([H])C(C[C@H](OC(C(CO)=C)=O)[C@](C3=C)([H])[C@]2([H])OC3=O)=C
InChi Code
InChI=1S/C19H22O6/c1-8-5-14(24-18(22)9(2)7-20)16-11(4)19(23)25-17(16)15-10(3)13(21)6-12(8)15/h12-17,20-21H,1-7H2/t12-,13-,14-,15-,16+,17+/m0/s1
InChi Key
KHSCYOFDKADJDJ-NQLMQOPMSA-N
Origin
Plant/Cynara scolymus leaf
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 2 years
| SKU | CAYM-25099-1 |
|---|---|
| Supplier Part Number | 25099-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| CAS Number | 35730-78-0 |
| Energy Star | No |
| Green | No |
| Controlled | N |