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Cayman Luteoloside
List Price $143.00 Your Price $143.00
Cayman Luteoloside - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-25141-10
MFG.PART: 25141-10
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Luteoloside is a flavonoid that has been found in many Chinese herbs with diverse biological activities.,,, It reduces lactate dehydrogenase (LDH) and caspase-3 activities and production of reactive oxygen species (ROS) and increases cell viability and 14-3-3η protein levels in H9C2 cardiomyocytes after anoxia/reoxygenation injury. Luteoloside blocks 3C protease activity (IC50 = 0.36 mm) and reduces the cytopathic effect of enterovirus 71 in rhabdomyosarcoma cells (EC50 = 0.43 mm). It inhibits the growth of hepatocellular carcinoma (HCC) cells in vitro via reduction in ROS accumulation, caspase-1 activity, and expression of the NLRP3 inflammasome and reduces the number of lung metastases in an SMMC-7721 HCC mouse xenograft model when administered at a dose of 2 mg/kg. Luteoloside also reduces acanthosis and expression of epidermal differentiation markers in a mouse model of psoriasis induced by imiquimod (Item No. ).
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-(3,4-dihydroxy
CAS Number
5373-11-5
Synonyms
- Cynaroside
- Luteolin 7-β-D-Glucopyranoside
- Luteolin 7-O-Glucoside
Molecular Formula
C21H20O11
Formula Weight
448.4
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 20 mg/mL
- DMSO: 10 mg/mL
- DMSO:PBS (pH 7.2) (1:5): 1 mg/mL
- Ethanol: 5 mg/mL
λmax
256, 350 nm
SMILES
OC1=C(C(C=C(C2=CC(O)=C(O)C=C2)O3)=O)C3=CC(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O4)=C1
InChi Code
InChI=1S/C21H20O11/c22-7-16-18(27)19(28)20(29)21(32-16)30-9-4-12(25)17-13(26)6-14(31-15(17)5-9)8-1-2-10(23)11(24)3-8/h1-6,16,18-25,27-29H,7H2/t16-,18-,19+,20-,21-/m1/s1
InChi Key
PEFNSGRTCBGNAN-QNDFHXLGSA-N
Origin
Plant/Lonicera japonica
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-25141-10 |
|---|---|
| Supplier Part Number | 25141-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 5373-11-5 |
| Energy Star | No |
| Green | No |
| Controlled | N |