Cayman STING A162 variant (human, recombinant)

STING A162 variant (human recombinant) contains amino acids 138-379 of the wild-type variant (R232) with an alanine substituted for serine at position 162. Stimulator of interferon genes (STING) is a component of the innate immune response that binds to cyclic dinucleotides, which are bacterial second messengers, leading to activation of NF-κB and transcription of immunomodulatory genes, including type I interferon (IFN).^,,, The R232 variant of STING is the most common variant in the human population, found at a frequency of 57.9% in the 1000 Genome Project. The SNP variant H232 is found at a 13.7% frequency. The S162A point mutation is located in the cyclic dinucleotide binding site of the human STING variants R232 and H232 and allows human STING to bind to DMXAA, a compound previously known to bind mouse, but not human, STING.^, When STING S162A is bound to DMXAA, it adopts the closed conformation, similar to the conformation it has when bound to the second messenger 2’3’-cGAMP (Item No. ), and activates the IFN pathway similarly to mouse STING.

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