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Cayman Anastrozole-d12
List Price $236.00 Your Price $236.00
Cayman Anastrozole-d12 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-25360-1
MFG.PART: 25360-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Anastrozole-d12 is intended for use as an internal standard for the quantification of anastrozole (Item No. ) by GC- or LC-MS. Anastrozole is an aromatase/CYP19A1 inhibitor (IC50 = 15 nM for human placental aromatase/CYP19A1). It is selective for aromatase/CYP19A1 over the cytochrome P450 (CYP) isoforms CYP1A2, CYP2A6, CYP2C9, CYP2D6, and CYP3A (IC50s = 27-650 μM). Anastrozole (0.1 mg/kg) blocks ovulation in mature female rats and androstenedione-stimulated uterine development in pubertal female rats. It inhibits peripheral aromatase/CYP19A1 and reduces plasma estradiol concentrations in male pigtailed monkeys when administered at doses greater than 0.1 mg/kg. Anastrozole (0.5 mg/kg) reduces tumor incidence and the number of tumors by 40 and 57%, respectively, as well as increases latency to tumor appearance in a rat model of premenopausal mammary tumorigenesis. Formulations containing anastrozole have been used in the treatment of breast cancer.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
α,α,α,α-tetra(methyl-d3)-5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-benzenediacetonitrile
CAS Number
120512-32-5
Synonyms
- Anastrol-d12
Molecular Formula
C17H7D12N5
Formula Weight
305.4
Purity
≥99% deuterated forms (d1-d12)
Formulation
A solid
Solubility
- Chloroform: Soluble
SMILES
[2H]C([2H])([2H])C(C([2H])([2H])[2H])(C#N)C1=CC(C(C([2H])([2H])[2H])(C#N)C([2H])([2H])[2H])=CC(CN2C=NC=N2)=C1
InChi Code
InChI=1S/C17H19N5/c1-16(2,9-18)14-5-13(8-22-12-20-11-21-22)6-15(7-14)17(3,4)10-19/h5-7,11-12H,8H2,1-4H3/i1D3,2D3,3D3,4D3
InChi Key
YBBLVLTVTVSKRW-MGKWXGLJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-25360-1 |
|---|---|
| Supplier Part Number | 25360-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | Canada |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 120512-32-5 |
| Energy Star | No |
| Green | No |
| Controlled | N |