Cayman PSB-603

PSB-603 is an antagonist of the adenosine A_2B receptor (K_i = 0.553 nM). It is selective for adenosine A_2B over A₁, A_2A, and A₃ receptors (K_is = >10,000 nM). It reduces intracellular calcium concentrations in Jurkat T cells expressing the human A_2B receptor (IC₅₀ = 1.13 nM). PSB-603 reduces Zika viral plaque formation (IC₅₀ = 43.8 nM) without affecting cell viability of A549 cells when used at concentrations up to 1 µM. In vivo, PSB-603 (0.25 µg/head, i.p.) delays tumor growth and reduces tumor volume and the number of pulmonary metastases in the B16 mouse model of melanoma via inhibition of induction of regulatory T cells.

WARNING This product is not for human or veterinary use.