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Cayman ODM-201
List Price
$49.00
Your Price
$49.00
Cayman ODM-201 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-25643-1
MFG.PART:
25643-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
ODM-201 is an androgen receptor (AR) antagonist (Ki = 11 nM). It inhibits AR transactivation in U2OS osteosarcoma cells expressing human wild-type and mutant ARs (IC50s = 65, 66, 1,500, and 1,782 nM for wild-type, ARF876L, ARW741L, and ART877A, respectively). ODM-201 prevents androgen-induced AR nuclear translocation in AR-overexpressing HS-HEK293 and LNCaP cells and suppresses androgen-induced proliferation of VCaP cells (IC50 = 230 nM). In vivo, ODM-201 (50 mg/kg per day) reduces tumor growth in a VCaP castrated mouse xenograft model. It also inhibits tumor growth without increasing serum testosterone levels in a VCaP intact mouse xenograft model.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[(1S)-2-[3-
CAS Number
1297538-32-9
Synonyms
- BAY 1841788
Molecular Formula
C19H19ClN6O2
Formula Weight
398.9
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 25 mg/mL
- DMSO: 25 mg/mL
- DMSO:PBS(pH 7.2) (1:3): 0.25 mg/mL
- Ethanol: 10 mg/mL
λmax
288 nm
SMILES
OC(C)C1=CC(C(N[C@@H](C)CN2C=CC(C3=CC=C(C#N)C(Cl)=C3)=N2)=O)=NN1
InChi Code
InChI=1S/C19H19ClN6O2/c1-11(22-19(28)18-8-17(12(2)27)23-24-18)10-26-6-5-16(25-26)13-3-4-14(9-21)15(20)7-13/h3-8,11-12,27H,10H2,1-2H3,(H,22,28)(H,23,24)/t11-,12?/m0/s1
InChi Key
BLIJXOOIHRSQRB-PXYINDEMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-25643-1 |
|---|---|
| Supplier Part Number | 25643-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| CAS Number | 1297538-32-9 |
| Energy Star | No |
| Green | No |
| Controlled | N |