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Cayman Tropifexor
List Price
$94.00
Your Price
$94.00
Cayman Tropifexor - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-25748-1
MFG.PART:
25748-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Tropifexor is an agonist of farnesoid X receptors (FXR). It enhances the interaction between the human FXR ligand binding domain and the steroid receptor coactivator 1 (SRC-1) peptide in a homogeneous time-resolved fluorescence (HTRF) coactivator interaction assay (EC50 = 0.2 nM). It increases expression of the FXR target genes BSEP and SHP and decreases expression of CPY8B1 in rat liver in a dose-dependent manner, as well as increases expression of SHP and FGF15 in rat ileum. Tropifexor (0.3 mg/kg) reduces triglyceride levels by 79% in rat serum. It reduces fibrosis, inflammation, and steatosis in a mouse model of nonalcoholic steatohepatitis (NASH).
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-[(3-endo)-
CAS Number
1383816-29-2
Synonyms
- LJN452
Molecular Formula
C29H25F4N3O5S
Formula Weight
603.6
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMSO: 10 mg/mL
λmax
313 nm
SMILES
FC1=C2C(SC(N3[C@H]4CC[C@@H]3C[C@H](OCC5=C(C6CC6)ON=C5C7=CC=CC=C7OC(F)(F)F)C4)=N2)=CC(C(O)=O)=C1
InChi Code
InChI=1S/C29H25F4N3O5S/c30-21-9-15(27(37)38)10-23-25(21)34-28(42-23)36-16-7-8-17(36)12-18(11-16)39-13-20-24(35-41-26(20)14-5-6-14)19-3-1-2-4-22(19)40-29(31,32)33/h1-4,9-10,14,16-18H,5-8,11-13H2,(H,37,38)/t16-,17+,18+
InChi Key
VYLOOGHLKSNNEK-PIIMJCKOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-25748-1 |
|---|---|
| Supplier Part Number | 25748-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1383816-29-2 |
| Energy Star | No |
| Green | No |
| Controlled | N |