Cayman Lysophosphatidylethanolamine (egg)

Lysophosphatidylethanolamine (LPE) is a naturally-occurring lysophospholipid that can be generated via deacylation of phosphatidylethanolamine by phospholipase A₂ (PLA₂).^1,2 It increases the phosphorylation of ERK1/2 in PC12 cells, an effect that can be blocked by the MEK inhibitors U-0126 (Item No. 70970) and PD 98059 (Item No. 10006726) and the EGFR inhibitor AG-1478 (Item No. 10010244).¹ LPE also increases neurite outgrowth and expression of neurofilament M in PC12 cells. LPE inhibits the activity of phospholipase D (PLD) partially purified from cabbage.³ This product contains lysophosphatidylethanolamine molecular species with variable fatty acyl chain lengths at the sn-1 position and a hydroxy group at the sn-2 position.

WARNING This product is not for human or veterinary use.