Cayman Para-Fluoro 4-Anbp; Purity- Greater Than Or Equal To 98%;

IT-901 is an inhibitor of the NF-κB subunit c-Rel. It inhibits NF-κB DNA binding in HBL1 cells (IC₅₀ = 0.1 µM) and reduces TNF-α-induced NF-κB activity in a reporter assay (IC₅₀ = 4 µM). IT-901 decreases proliferation of activated B-like (ABC) and germinal center B-like (GCB) human diffuse large B cell lymphoma (DLBCL) cells when used at a concentration of 3 µM. It increases the expression of heme oxygenase-1 (HO-1; Item No. ) in DLBCL cells and increases the production of reactive oxygen species (ROS) in the mitochondria of DLBCL cells but not normal leukocytes. IT-901 increases survival in a mouse model of graft versus host disease (GVHD) when administered at a dose of 24 mg/kg every other day beginning eight days after hematopoietic stem cell transplantation (HSCT). It also reduces tumor growth in mouse xenograft models of B cell lymphoma induced by Epstein-Barr virus (EBV), chronic lymphocytic leukemia (CLL), and Richter syndrome.^,

WARNING This product is not for human or veterinary use.