Cayman Lysophosphatidylinositol (porcine liver) (sodium salt)

Lysophosphatidylinositols (LPIs) are bioactive lysophospholipids formed via phospholipase A₁ (PLA₁) or PLA₂ catabolism of phosphatidylinositol (Item No. ). They are produced in a variety of cells including human platelets, endothelial cells, and neutrophils and are found in the central and peripheral nervous system. LPIs containing stearic acid (Item No. ) are the primary form found in rat brain followed by LPIs containing arachidonic acid (Item Nos. | ), and both are agonists of the g protein-coupled receptor GPR55, with 2-arachidonoyl LPI having higher activity than 2-stearoyl LPI. LPIs also induce exocytotic release of insulin by pancreatic islet cells and intracellular calcium mobilization in a variety of cells, as well as increase ERK1/2, Akt, and p38 phosphorylation via GPR55 activation.^, LPIs accumulate in transformed cell lines due to increased PLA₂ activity and blood levels are higher in patients with ovarian or peritoneal cancers compared with healthy controls.^, This product contains lysophosphatidylinositol molecular species with variable fatty acyl chain lengths at the sn-1 position and a hydroxy group in the sn-2 position.

WARNING This product is not for human or veterinary use.