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Cayman NIH 12848
List Price $41.00 Your Price $41.00
Cayman NIH 12848 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-26035-1
MFG.PART: 26035-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
NIH 12848 is an inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ; IC50 = ~1 µM). It is selective for PI5P4Kγ over PI5P4Kα and PI5P4Kβ (IC50s = >100 µM). NIH 12848 inhibits translocation of the Na+/K+-ATPase to the plasma membrane in mouse principal kidney cortical collecting duct (mpkCCD) cells. NIH 12848 is also an inhibitor of USP1/UAF complex deubiquitinase activity (IC50 = 7.9 µM). It increases accumulation of monoubiquitinated proliferating cell nuclear antigen (PCNA) in H1299 non-small cell lung cancer (NSCLC) cells when used at a concentration of 20 µM.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-(2-thienyl
CAS Number
959551-10-1
Molecular Formula
C20H14F3N3S
Formula Weight
385.4
Purity
≥95%
Formulation
A crystalline solid
Solubility
- DMSO: 25 mg/mL
λmax
231, 317 nm
SMILES
FC(C(C=CC=C1)=C1C2=NC3=CC=CC=C3C(NCC4=CC=CS4)=N2)(F)F
InChi Code
InChI=1S/C20H14F3N3S/c21-20(22,23)16-9-3-1-7-14(16)19-25-17-10-4-2-8-15(17)18(26-19)24-12-13-6-5-11-27-13/h1-11H,12H2,(H,24,25,26)
InChi Key
QBDAEJRHUCSSPR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-26035-1 |
|---|---|
| Supplier Part Number | 26035-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 959551-10-1 |
| Energy Star | No |
| Green | No |
| Controlled | N |