Cayman NIH 12848

NIH 12848 is an inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ; IC₅₀ = ~1 µM).¹ It is selective for PI5P4Kγ over PI5P4Kα and PI5P4Kβ (IC₅₀s = >100 µM). NIH 12848 inhibits translocation of the Na⁺/K⁺-ATPase to the plasma membrane in mouse principal kidney cortical collecting duct (mpkCCD) cells. NIH 12848 is also an inhibitor of USP1/UAF complex deubiquitinase activity (IC₅₀ = 7.9 µM).² It increases accumulation of monoubiquitinated proliferating cell nuclear antigen (PCNA) in H1299 non-small cell lung cancer (NSCLC) cells when used at a concentration of 20 µM.

WARNING This product is not for human or veterinary use.