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Cayman A01
List Price
$193.00
Your Price
$193.00
Cayman A01 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-26137-10
MFG.PART:
26137-10
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
A01 is an inhibitor of Smad ubiquitination regulatory factor 1 (Smurf1) ubiquitin ligase (Kd = 3.67 nM). It inhibits Smurf1-mediated ubiquitination of Smad1/5 and increases Smad1/5 protein levels in C2C12 cells stimulated with bone morphogenic protein 2 (BMP2) in a concentration-dependent manner. A01 (2 μM) increases BMP2-induced mRNA expression of alkaline phosphatase (ALP), osteocalcin, and type-1 collagen in MC3T3-E1 mouse pre-osteoblasts.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
[4-[[4-
CAS Number
1007647-73-5
Molecular Formula
C22H20ClF3N4O3S
Formula Weight
512.9
Purity
≥95%
Formulation
A crystalline solid
Solubility
- DMF: 25mg/mL
- DMF:PBS (pH 7.2) (1:3): 0.25mg/mL
- DMSO: 15mg/mL
λmax
277 nm
SMILES
ClC1=CC=C(S(N2CCN(C(C3=CC=C(N4C(C)=CC=N4)C=C3)=O)CC2)(=O)=O)C=C1C(F)(F)F
InChi Code
InChI=1S/C22H20ClF3N4O3S/c1-15-8-9-27-30(15)17-4-2-16(3-5-17)21(31)28-10-12-29(13-11-28)34(32,33)18-6-7-20(23)19(14-18)22(24,25)26/h2-9,14H,10-13H2,1H3
InChi Key
QFYLTUDRXBNZFQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-26137-10 |
|---|---|
| Supplier Part Number | 26137-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1007647-73-5 |
| Energy Star | No |
| Green | No |
| Controlled | N |