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Cayman SZL P1-41
List Price
$542.00
Your Price
$542.00
Cayman SZL P1-41 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-26142-25
MFG.PART:
26142-25
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
SZL P1-41 is an inhibitor of the Skp1-Cullin1-F-box (SCF) family protein Skp2.1 It inhibits the interaction between Skp2 and Skp1 to block Skp2 E3 ubiquitin ligase activity when used at a concentration of 5 μM. SZL P1-41 selectively inhibits Skp2 over Fbw7 and β-TrCP E3 ubiquitin ligase activity in HEK293T cells. It reduces survival of LNCaP and PC3 prostate cancer cells in a concentration-dependent manner via inhibition of aerobic glycolysis and induction of apoptosis. SZL P1-41 (40 and 80 mg/kg) reduces tumor volume in A549 lung cancer and PC3 prostate cancer mouse xenograft models.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
3-(2-benzo
CAS Number
222716-34-9
Molecular Formula
C24H24N2O3S
Formula Weight
420.5
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 1 mg/mL
- DMSO: 0.3 mg/mL
- Ethanol: 0.3 mg/mL
λmax
224, 264, 308
SMILES
O=C1C(C2=NC3=C(C=CC=C3)S2)=COC4=C1C=C(CC)C(O)=C4CN5CCCCC5
InChi Code
InChI=1S/C24H24N2O3S/c1-2-15-12-16-22(28)18(24-25-19-8-4-5-9-20(19)30-24)14-29-23(16)17(21(15)27)13-26-10-6-3-7-11-26/h4-5,8-9,12,14,27H,2-3,6-7,10-11,13H2,1H3
InChi Key
JKIXLEKBXHMXTN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-26142-25 |
|---|---|
| Supplier Part Number | 26142-25 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 222716-34-9 |
| Energy Star | No |
| Green | No |
| Controlled | N |