Cayman N-Desmethylclozapine

N-Desmethylclozapine is an active metabolite of the atypical antipsychotic clozapine (Item Nos. 12059 | 25779).¹ It was originally described as an antagonist of serotonin (5-HT) receptor subtype 5-HT_2C (IC₅₀ = 7.1 nM in rat choroid plexus) and later as an inverse agonist using human recombinant receptors.^2,3 N-Desmethylclozapine is an antagonist at dopamine D₄ receptors, an agonist at δ-opioid receptors, and a partial agonist at dopamine D₂ and D₃, M₁ muscarinic acetylcholine, and 5-HT_1A receptors.^3,1,4 N-Desmethylclozapine (30 mg/kg) decreases exploratory locomotor activity and increases prepulse inhibition of the acoustic startle response in mice.⁵

WARNING This product is not for human or veterinary use.