We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn about our cookie policy.
Cayman Verdinexor
List Price $32.00 Your Price $32.00
Cayman Verdinexor - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-26171-1
MFG.PART: 26171-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Verdinexor is a reversible inhibitor of Exportin I (XPO1/CRM1) with anticancer and antiviral activities.,, It inhibits the growth of OCI-Ly3, OCI-Ly10, and CLBL1 diffuse large B cell lymphoma (DLBCL) cells (IC50s = 2.1, 41.8, and 8.5 nM, respectively). Verdinexor inhibits XPO1/CRM1-mediated nuclear transport of respiratory syncytial virus (RSV) M protein when used at concentrations greater than 1 μM. It reduces RSV A2 replication (IC50 = 0.96 μM) without affecting viability of A549 cells (CC50 = >38 μM). In vivo, verdinexor (20 mg/kg) reduces virus shedding, pulmonary TNF-α, IL-6, MCP-1, and IFN-γ expression, and leukocyte infiltration into the bronchoalveolar space in a mouse model of influenza A viral infection. It also reduces viral burden in a ferret model of influenza A viral infection.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(2Z)-3-[3-
CAS Number
1392136-43-4
Synonyms
- KPT-335
Molecular Formula
C18H12F6N6O
Formula Weight
442.3
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMSO: 88 mg/mL
- Ethanol: 11 mg/mL
λmax
232, 273 nm
SMILES
O=C(NNC1=CC=CC=N1)/C=C\N2C=NC(C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)=N2
InChi Code
InChI=1S/C18H12F6N6O/c19-17(20,21)12-7-11(8-13(9-12)18(22,23)24)16-26-10-30(29-16)6-4-15(31)28-27-14-3-1-2-5-25-14/h1-10H,(H,25,27)(H,28,31)/b6-4-
InChi Key
OPAKEJZFFCECPN-XQRVVYSFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-26171-1 |
|---|---|
| Supplier Part Number | 26171-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1392136-43-4 |
| Energy Star | No |
| Green | No |
| Controlled | N |