We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn about our cookie policy.
Cayman 4SC-202
List Price
$1,077.00
Your Price
$1,077.00
Cayman 4SC-202 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-26175-50
MFG.PART:
26175-50
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
4SC-202 is an inhibitor of the class I histone deacetylases (HDACs) HDAC1-3 and the histone demethylase KDM1A.1 It reduces cell viability in a panel of colorectal cancer (CRC) cell lines when used at concentrations ranging from 1 to 10 µM and in patient-derived CRC cell lines when used at a concentration of 5 µM.2 4SC-202 (5 µM) induces cell cycle arrest at the g2/M phase in HT-29 cells and primary human CRC cells and increases apoptosis in HT-29 cells in a concentration-dependent manner, an effect that is enhanced by the Akt inhibitors perifosine (Item No. 10008112) and MK-2206 (Item No. 11593). 4SC-202 (100 mg/kg, p.o., every other day) reduces tumor growth in an HT-29 mouse xenograft model when administered alone and to an enhanced degree when co-administered with oxaliplatin (Item No. 13106).
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(2E)-N-(2-
CAS Number
1186222-89-8
Molecular Formula
C23H21N5O3S • C7H8O3S
Formula Weight
619.7
Purity
≥98%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- DMSO: soluble
SMILES
O=S(C1=CC=C(C2=CN(C)N=C2)C=C1)(N3C=C(/C=C/C(NC4=C(N)C=CC=C4)=O)C=C3)=O.CC5=CC=C(S(O)(=O)=O)C=C5
InChi Code
InChI=1S/C23H21N5O3S.C7H8O3S/c1-27-16-19(14-25-27)18-7-9-20(10-8-18)32(30,31)28-13-12-17(15-28)6-11-23(29)26-22-5-3-2-4-21(22)24;1-6-2-4-7(5-3-6)11(8,9)10/h2-16H,24H2,1H3,(H,26,29);2-5H,1H3,(H,8,9,10)/b11-6+;
InChi Key
IAVXAZDVNICKFJ-ICSBZGNSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-26175-50 |
|---|---|
| Supplier Part Number | 26175-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| CAS Number | 1186222-89-8 |
| Energy Star | No |
| Green | No |
| Controlled | N |