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Cayman O-304
List Price
$65.00
Your Price
$65.00
Cayman O-304 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-26186-1
MFG.PART:
26186-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
O-304 is a pan-activator of AMP-activated protein kinase (AMPK). It increases levels of phosphorylated AMPK (pAMPK) without reducing cellular ATP. O-304 suppresses dephosphorylation of AMPKα, AMPKβ, and AMPKγ trimers at threonine 172 (T172) mediated by protein phosphatase 2C (PP2C) without inhibiting PP2C activity in Wi-38 lung fibroblasts. In vivo, O-304 (100 mg/kg) prevents high-fat diet-induced increases in fasted glucose and plasma insulin levels and development of insulin resistance, as well as increases calf muscle pAMPK levels in mice.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4-chloro-N-
CAS Number
1261289-04-6
Molecular Formula
C16H11Cl2N3O2S
Formula Weight
380.2
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 10 mg/mL
- DMSO: 10 mg/mL
- DMSO:PBS (pH 7.2) (1:30): 0.03 mg/mL
- Ethanol: slightly soluble
λmax
256, 320 nm
SMILES
ClC1=CC=C(CN2SC(NC(C3=CC=C(Cl)C=C3)=O)=NC2=O)C=C1
InChi Code
InChI=1S/C16H11Cl2N3O2S/c17-12-5-1-10(2-6-12)9-21-16(23)20-15(24-21)19-14(22)11-3-7-13(18)8-4-11/h1-8H,9H2,(H,19,20,22,23)
InChi Key
WEDWLYRQKUTOAX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-26186-1 |
|---|---|
| Supplier Part Number | 26186-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1261289-04-6 |
| Energy Star | No |
| Green | No |
| Controlled | N |