Cayman Zymostenol

Zymostenol is a late-stage precursor in the biosynthesis of cholesterol.¹ It is an agonist of retinoic acid receptor-related orphan receptor γ (RORγ) with an EC₅₀ value of 1 µM in a RORγ coactivator recruitment assay in the presence of ursolic acid (Item No. 10072). It increases the number of myelin basic protein-positive oligodendrocytes generated from oligodendrocyte precursor cells in vitro.² Zymostenol accumulates in cells following administration of microsomal antiestrogen-binding site (AEBS) ligands, such as tamoxifen (Item No. 13258), which are associated with cell differentiation and a protective type of autophagy.^3,4 When used alone at a concentration of 20 µM, zymostenol halts the cell cycle at the g₀/g₁ phase and increases the levels of free sterols, esterified sterols, and triacylglycerols in MCF-7 cells.³

WARNING This product is not for human or veterinary use.