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Cayman CC-122
List Price $32.00 Your Price $32.00
Cayman CC-122 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-26257-10
MFG.PART: 26257-10
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
CC-122 is a pleiotropic pathway modifier with anticancer activity.1 It binds to cereblon, a substrate receptor protein of the Cullin 4 RING E3 ubiquitin ligase complex, in U266 multiple myeloma cell extracts and induces recruitment and degradation of the cereblon substrates Aiolos and Ikaros in TMD8, OCI-LY10, and Karpas 422 diffuse large B cell lymphoma (DLBCL) cells when used at concentrations of 0.1, 1, and 10 μM. CC-122 (0.1-10,000 nM) decreases proliferation and induces apoptosis in activated B cell (ABC) and germinal center B cell (GCB) DLBCL cell lines. It also stimulates IL-2 production in mouse primary T cells. CC-122 (30 mg/kg) decreases tumor levels of Aiolos and Ikaros and reduces tumor growth in OCI-LY10 ABC DLBCL and WSU-DLCL2 GCB DLBCL mouse xenograft models.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
3-(5-amino-
CAS Number
1015474-32-4
Synonyms
- Avadomide
Molecular Formula
C14H14N4O3
Formula Weight
286.3
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- DMSO:PBS (pH 7.2) (1:2): 0.33 mg/mL
λmax
239, 358 nm
SMILES
O=C1C2=C(N)C=CC=C2N=C(C)N1C3CCC(NC3=O)=O
InChi Code
InChI=1S/C14H14N4O3/c1-7-16-9-4-2-3-8(15)12(9)14(21)18(7)10-5-6-11(19)17-13(10)20/h2-4,10H,5-6,15H2,1H3,(H,17,19,20)
InChi Key
RSNPAKAFCAAMBH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-26257-10 |
|---|---|
| Supplier Part Number | 26257-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1015474-32-4 |
| Energy Star | No |
| Green | No |
| Controlled | N |