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Cayman A-966492
List Price $36.00 Your Price $36.00
Cayman A-966492 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-26378-1
MFG.PART: 26378-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
A-966492 is a dual inhibitor of poly(ADP-ribose) polymerase 1 (PARP1) and PARP2 (Kis = 1 and 1.5 nM, respectively). It reduces tumor growth by 46 and 92% in an MX-1 mouse xenograft model when administered at doses of 100 and 200 mg/kg per day, respectively. A-966492 also reduces tumor growth in a B16/F10 murine melanoma model when administered in combination with temozolomide (Item No. ).
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-[2-fluoro-4-
CAS Number
934162-61-5
Molecular Formula
C18H17FN4O
Formula Weight
324.4
Purity
≥98%
Formulation
A solid
Solubility
- DMSO: soluble
SMILES
NC(C1=C(NC(C2=CC=C([C@H]3NCCC3)C=C2F)=N4)C4=CC=C1)=O
InChi Code
InChI=1S/C18H17FN4O/c19-13-9-10(14-5-2-8-21-14)6-7-11(13)18-22-15-4-1-3-12(17(20)24)16(15)23-18/h1,3-4,6-7,9,14,21H,2,5,8H2,(H2,20,24)(H,22,23)/t14-/m0/s1
InChi Key
AHIVQGOUBLVTCB-AWEZNQCLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-26378-1 |
|---|---|
| Supplier Part Number | 26378-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 934162-61-5 |
| Energy Star | No |
| Green | No |
| Controlled | N |