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Cayman ETC-1002
List Price
$135.00
Your Price
$135.00
Cayman ETC-1002 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-26409-50
MFG.PART:
26409-50
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
ETC-1002 is a prodrug form of ETC-1002-CoA.1 ETC-1002 is conjugated to coenzyme A (CoA) by very long-chain acyl-CoA synthetase-1 (ACSVL1) to form ETC-1002-CoA, which inhibits ATP citrate lyase (Ki = 2 μM) and activates AMP-activated protein kinase (AMPK). ETC-1002 suppresses total lipid synthesis in wild-type and AMPKβ1 knockout primary murine hepatocytes. In vivo, ETC-1002 (30 mg/kg) prevents increases in hepatic cholesterol and reduces the size of aortic atherosclerotic lesions induced by a high-fat high-cholesterol diet in Apoe-/-/Ampkβ1-/- (DKO) mice.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
8-hydroxy-
CAS Number
738606-46-7
Synonyms
- Bempedoic Acid
- ESP-55016
Molecular Formula
C19H36O5
Formula Weight
344.5
Purity
≥95%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 20 mg/mL
- DMSO: 20 mg/mL
- DMSO:PBS (pH 7.2) (1:2): 0.33 mg/mL
- Ethanol: 2 mg/mL
SMILES
OC(C(C)(C)CCCCCC(O)CCCCCC(C)(C)C(O)=O)=O
InChi Code
InChI=1S/C19H36O5/c1-18(2,16(21)22)13-9-5-7-11-15(20)12-8-6-10-14-19(3,4)17(23)24/h15,20H,5-14H2,1-4H3,(H,21,22)(H,23,24)
InChi Key
HYHMLYSLQUKXKP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-26409-50 |
|---|---|
| Supplier Part Number | 26409-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 738606-46-7 |
| Energy Star | No |
| Green | No |
| Controlled | N |