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Cayman Asimadoline
List Price
$462.00
Your Price
$462.00
Cayman Asimadoline - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-26411-25
MFG.PART:
26411-25
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Asimadoline is a potent κ-opioid receptor (KOR) agonist (IC50s = 5.6 and 1.2 nM for guinea pig and human receptors, respectively).1 It is 501- and 498-fold selective for κ-opioid over μ- and δ-opioid receptors, respectively. Asimadoline is spasmolytic in isolated rat duodenum (IC50 = 4.2 μM) and inhibits spontaneous contractions of isolated rat uterus (IC50 = 12.7 μM). In vivo, asimadoline reduces joint damage in a rat model of arthritis induced by complete Freunds adjuvant (CFA). Asimadoline (25 mg/kg) also reduces the abdominal withdrawal reflex in a model of visceral pain induced by colonic distension in wild-type, but not KOR-/-, mice.2
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[(1S)-2-
CAS Number
153205-46-0
Synonyms
- EMD 61753
Molecular Formula
C27H30N2O2
Formula Weight
414.5
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMSO: 103 mg/mL
SMILES
O=C(N([C@H](CN1C[C@@H](O)CC1)C2=CC=CC=C2)C)C(C3=CC=CC=C3)C4=CC=CC=C4
InChi Code
InChI=1S/C27H30N2O2/c1-28(25(21-11-5-2-6-12-21)20-29-18-17-24(30)19-29)27(31)26(22-13-7-3-8-14-22)23-15-9-4-10-16-23/h2-16,24-26,30H,17-20H2,1H3/t24-,25+/m0/s1
InChi Key
JHLHNYVMZCADTC-LOSJGSFVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-26411-25 |
|---|---|
| Supplier Part Number | 26411-25 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 153205-46-0 |
| Energy Star | No |
| Green | No |
| Controlled | N |