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Cayman Topiramate-d12
List Price
$868.00
Your Price
$868.00
Cayman Topiramate-d12 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-26443-10
MFG.PART:
26443-10
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Topiramate-d12 is intended for use as an internal standard for the quantification of topiramate (Item No. 13623) by GC- or LC-MS. Topiramate is a sugar sulfamate with anticonvulsant activity.1 It inhibits carbonic anhydrase in intact human erythrocytes (Ki = ~200 μM), as well as blocks sodium and calcium channels and kainate-induced currents in vitro.1,2,3 It also increases GABAA receptor-mediated chloride ion flux.3 Topiramate inhibits hind-limb tonic-extensor seizures in the maximal electroshock seizure test in mice (ED50 = 39 mg/kg, p.o.).1 Formulations containing topiramate have been used in the treatment of epilepsy and prophylaxis of migraine headaches.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2,3:4,5-bis-O-
CAS Number
1279037-95-4
Synonyms
- TPM-d12
Molecular Formula
C12H9D12NO8S
Formula Weight
351.4
Purity
≥99% deuterated forms (d1-d12)
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- DMF: 25 mg/mL
- DMSO: 15 mg/mL
- Ethanol: 20 mg/mL
- PBS (pH 7.2): 0.1 mg/mL
SMILES
NS(OC[C@]12[C@@H](OC(C([2H])([2H])[2H])(C([2H])([2H])[2H])O2)[C@H]3[C@H](OC(C([2H])([2H])[2H])(C([2H])([2H])[2H])O3)CO1)(=O)=O
InChi Code
InChI=1S/C12H21NO8S/c1-10(2)18-7-5-16-12(6-17-22(13,14)15)9(8(7)19-10)20-11(3,4)21-12/h7-9H,5-6H2,1-4H3,(H2,13,14,15)/t7-,8-,9+,12+/m1/s1/i1D3,2D3,3D3,4D3
InChi Key
KJADKKWYZYXHBB-RFYKXYJISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-26443-10 |
|---|---|
| Supplier Part Number | 26443-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | Canada |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1279037-95-4 |
| Energy Star | No |
| Green | No |
| Controlled | N |