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Cayman Dorzolamide-d5 (hydrochloride)
List Price $294.00 Your Price $294.00
Cayman Dorzolamide-d5 (hydrochloride) - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-26518-1
MFG.PART: 26518-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Dorzolamide-d5 is intended for use as an internal standard for the quantification of dorzolamide (Item No. ) by GC- or LC-MS. Dorzolamide is an inhibitor of carbonic anhydrase (CA), inhibiting CAII, CAV, CAVI, CAIX, CAXII, CAXIII, and CAXIV with Ki values ranging from 3.5 to 52 nM.,, It is selective for these isoforms over CAI, CAIII, and CAIV (Kis = 50, 8, and 8.5 μM, respectively). Dorzolamide inhibits carbonic anhydrase in isolated rabbit iris-ciliary body by 87% when used at a concentration of 0.02%. It also reduces intraocular pressure in an α-chymotrypsin-treated rabbit model of ocular hypertension and in normotensive rabbits when applied topically at a concentration of 0.5%. Formulations containing dorzolamide have been used in the treatment of glaucoma.,
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(4S,6S)-4-
CAS Number
2749856-75-3
Synonyms
- L-671,152-d5
- MK-507-d5
Molecular Formula
C10H11D5N2O4S3 • HCl
Formula Weight
365.9
Purity
≥99% deuterated forms (d1-d5)
Formulation
A solid
Solubility
- DMSO: soluble
- Methanol: soluble
SMILES
O=S1([C@@H](C)C[C@H](NC([2H])([2H])C([2H])([2H])[2H])C2=C1SC(S(N)(=O)=O)=C2)=O.Cl
InChi Code
InChI=1S/C10H16N2O4S3.ClH/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16;/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16);1H/t6-,8-;/m0./s1/i1D3,3D2;
InChi Key
OSRUSFPMRGDLAG-NOHQPKBYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-26518-1 |
|---|---|
| Supplier Part Number | 26518-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | Canada |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 2749856-75-3 |
| Energy Star | No |
| Green | No |
| Controlled | N |