We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
Cayman A-Hydroxy Flubromazolam
List Price
$469.00
Your Price
$469.00
Cayman A-Hydroxy Flubromazolam - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-26588-5
MFG.PART:
26588-5
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
The wild-type p53-induced phosphatase Wip1, also known as protein phosphatase magnesium-dependent 1 delta (PPM1D) or PP2Cδ, modulates cell cycling and may contribute to some forms of cancer., GSK2830371 is a potent inhibitor of Wip1 (IC50 = 6 nM). It displays selectivity for Wip1 over 21 other phosphatases. GSK2830371 increases phosphorylation of Wip1 substrates and blocks cell cycling in hematopoietic cancer cells and in Wip1-amplified cancer cells with wild-type p53. This compound is orally bioavailable and causes inhibition of lymphoma xenograft growth in mice.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
5-[[(5-chloro-2-methyl-3-pyridinyl)amino]methyl]-N-[(1S)-1-(cyclopentylmethyl)-2-(cyclopropylamino)-2-oxoethyl]-2-thiophenecarboxamide
CAS Number
1404456-53-6
Molecular Formula
C23H29ClN4O2S
Formula Weight
461.0
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/ml
- DMF:PBS (pH 7.2) (1:5): 0.1 mg/ml
- DMSO: 25 mg/ml
- Ethanol: 25 mg/ml
λmax
229, 255 nm
SMILES
ClC1=CC(NCC2=CC=C(C(N[C@H](C(NC3CC3)=O)CC4CCCC4)=O)S2)=C(C)N=C1
InChi Code
InChI=1S/C23H29ClN4O2S/c1-14-19(11-16(24)12-25-14)26-13-18-8-9-21(31-18)23(30)28-20(10-15-4-2-3-5-15)22(29)27-17-6-7-17/h8-9,11-12,15,17,20,26H,2-7,10,13H2,1H3,(H,27,29)(H,28,30)/t20-/m0/s1
InChi Key
IVDUVEGCMXCMSO-FQEVSTJZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-26588-5 |
|---|---|
| Featured | No |
| Supplier Part Number | 26588-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 2204237-96-5 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |