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Cayman CP 671,305
List Price $213.00 Your Price $213.00
Cayman CP 671,305 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-26743-5
MFG.PART: 26743-5
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
CP 671,305 is a potent inhibitor of phosphodiesterase 4D (PDE4D; IC50 = 3 nM).1 It is selective for PDE4D over PDE4A, -B, and -C (IC50s = 310, 287, and 3,858 nM, respectively), as well as over PDE1-3 and 5 (IC50s = >5,000 nM for all). CP 671,305 inhibits release of leukotriene E4 (LTE4; Item No. 20410) from eosinophils (IC50 = 52 nM) and LTB4 (Item No. 20110) from neutrophils (IC50 = 106 nM). In vivo, CP 671,305 inhibits antigen-induced pulmonary eosinophil influx in cynomolgus monkeys in a dose-dependent manner.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(2R)-2-[4-
CAS Number
445295-04-5
Molecular Formula
C23H19FN2O7
Formula Weight
454.4
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 50 mg/mL
- DMSO: 25 mg/mL
- Ethanol: 3 mg/mL
- PBS (pH 7.2): 2 mg/mL
λmax
279 nm
SMILES
OC([C@@H](C)OC1=CC(F)=C(CNC(C2=CC=CN=C2OC3=CC=C(OCO4)C4=C3)=O)C=C1)=O
InChi Code
InChI=1S/C23H19FN2O7/c1-13(23(28)29)32-15-5-4-14(18(24)9-15)11-26-21(27)17-3-2-8-25-22(17)33-16-6-7-19-20(10-16)31-12-30-19/h2-10,13H,11-12H2,1H3,(H,26,27)(H,28,29)/t13-/m1/s1
InChi Key
CNIGFESSDPOCKS-CYBMUJFWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-26743-5 |
|---|---|
| Supplier Part Number | 26743-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 445295-04-5 |
| Energy Star | No |
| Green | No |
| Controlled | N |